Crank meltdown in progress. Leroy Cronin, who published that ridiculous “assembly theory” article in Nature has been struggling for the last few ways to cope with the ridicule coming his way.

‘Everyone who disagrees with me is a troll!’ is not the triumphant comeback you think it is. Yes, it’s a theory that combines a lot of disciplines, I agree. But has he considered that maybe the reason he’s getting so much pushback is that people who actually know something about each of those disciplines is saying that the authors don’t understand how the discipline works? I can say that his paper didn’t get evolutionary biology at all right, so now I’m wondering if he also got theoretical physics, complexity theory, and prebiotic chemistry just as wrong.

I haven’t seen the creationists responding to assembly theory, but now I want to. Not hard enough to actually go digging, unfortunately.

Yikes. The kooks always claim to be leading a ‘paradigm shift’ and start quoting Kuhn.

Here’s another famous quote, this time from Carl Sagan.

“But the fact that some geniuses were laughed at does not imply that all who are laughed at are geniuses. They laughed at Columbus, they laughed at Fulton, they laughed at the Wright brothers. But they also laughed at Bozo the Clown.”

The fact that your ideas are laughed at is not evidence that you are correct.

Also, the fact that experts are triggered and reject your theory is not interesting, and doesn’t mean you’ve made a productive change in the world. Creationists trigger me too, that doesn’t validate creationism.

No one is offended. No one is beating people up. Cronin is being told that his ideas are wrong, which is what we’re supposed to do.

He’s feeling resentful about being corrected, nothing more. Well, also there should be some shame at publishing such a crappy article in a prestigious journal.

Finally, he reposts something from a supporter:

No one has said that. The origin of life is not solved and is most definitely a problem of interest. The catch is that assembly theory does not solve any of the problems anyone is wrestling with, and doesn’t seem to solve much of anything.

This is all reminding me of how Dr Wolfe-Simon reacted defensively to criticisms of her claim that life can substitute arsenic for phosphorus. Things got loud back in 2010, and she was insistent that she made a great discovery, but when was the last time you heard about arsenic life? The idea was dead within a year.

Let’s check back in Fall of 2024 and see how Cronin’s theory is holding up.

While the site was down, The Nobel Prize in Physiology or Medicine was awarded to Katalin Karikó and Drew Weissman for their work on mRNA viruses. This is exactly the kind of thing that deserves a prestigious award, since it was a fundamental discovery that opened the door for all kinds of scientific developments. It’s the personification of Faraday’s statement, “What good is a newborn baby?” and it also represents a conundrum — lots of science is done that is not immediately of use to others, but has undiscovered potential. I’m kind of impressed with Karikó’s struggle — she languished for years trying to do this work, yet she persevered.

Karikó, the 13th woman to win the prize, languished for many long years without funding or a permanent academic position, keeping her research afloat only by latching onto more senior scientists at the University of Pennsylvania who let her work with them. Unable to get a grant, she said she was told she was “not faculty quality” and was forced to retire from the university a decade ago. She remains only an adjunct professor there while she pursues plans to start a company with her daughter, Susan Francia, who has an MBA and was a two-time Olympic gold medalist in rowing.

The mRNA work was especially frustrating, she said, because it was met with indifference and a lack of funds. She said she was motivated by more than not being called a quitter; as the work progressed, she saw small signs that her project could lead to better vaccines. “You don’t persevere and repeat and repeat just to say, ‘I am not giving up,'” she said.

Universities, pay your adjuncts. Also, I hope UPenn doesn’t try to do any fundraising off this work by a researcher they disrespected.

I also just want to mention that I lived near her in Pennsylvania — I didn’t know her at all, but maybe fame was brushed off by proximity. She described how she got the news.

I was sleeping, and actually my husband picked up the phone. I am at my home in a suburb of Philadelphia in Abington township. And I was away in a conference in Cold Spring Harbor, and just Saturday returned. We celebrated 50 years of recombinant DNA technology. I met all of those people there, 80s, 90s that did the basic work, and I just came back.

My kids went to school in Abington! Neato!

I should note that, while academia didn’t appreciate her work and neglected her, capitalism saw some virtue.

But two biotech companies soon took notice: Moderna, in the United States, and BioNTech, in Germany, where Karikó eventually became a senior vice president. The companies studied the use of mRNA vaccines for flu, cytomegalovirus and other illnesses. None moved out of clinical trials for years.

I don’t think most adjunct faculty can fall back on their position as a senior vice president of a pharmaceutical company.

I wonder how many adjuncts are slaving away, struggling to get their work out there, and will never get this kind of acknowledgment? Probably something close to all of them.

Could a disease arise that killed half the human population? And that inflicted horrifying neurological effects as the victims slowly died? Sure could. It’s happened in other animals. It’s happening right now in moose.

Minnesota saw a 58% decline of the moose population in the northeastern part of the state between 2006 and 2017.

If you’ve ever seen a moose, you know they’re huge and intimidating — you don’t want to tangle with one. The bulls are temperamental and cranky, the cows are fiercely protective, and you really don’t want to have to deal with a 700kg angry beast. But here’s what’s bringing them low.

A primary driver of the decline is brainworm, a parasite that affects the animal’s nervous system ultimately leading to paralysis and death. Researchers from the University of Minnesota and the Grand Portage Band of Lake Superior Chippewa recently discovered evidence that moose in Minnesota consume species of gastropods —slugs and snails—which are known hosts for the brainworm parasite (Parelaphostrongylus tenuis).

This massive die-off is a consequence of climate change: the worm is moving north as the weather warms, migrating with resistant deer populations whose range is overlapping with that of moose. When people talk about new diseases accompanying climate shifts, this is the kind of thing we’re talking about.

It can happen to us, you know.

I do sometimes wonder if Republicans have been eating snails.

I can think of lots of candidates for the worst job humans could do. Commercial fishing is incredibly dangerous, and requires exhausting effort in miserable conditions. Stoop labor, like what we compel immigrants to do, is going to mess your body up in the long term, with chronic pain in the back and limbs, as well as being degradingly disrespected. You probably have your own examples of work that you would never want to do. But in my opinion, there is one job that is the ultimate worst.

Astronaut.

Human beings are not adapted to microgravity and high radiation. We’ve got enough data now on the consequences of long-term living in space (where long-term is a matter of months — no one is going to be able to live their lives in space).

Human bodies really can’t handle space. Spaceflight damages DNA, changes the microbiome, disrupts circadian rhythms, impairs vision, increases the risk of cancer, causes muscle and bone loss, inhibits the immune system, weakens the heart, and shifts fluids toward the head, which may be pathological for the brain over the long term—among other things.

It’s a devastating combination of effects with long-term consequences. A short hop into space, like billionaires like to play at, is one thing, but staying up their long enough for your physiology to try to adapt is another. It’s a long gamble in which you try to determine which systems fuck up first.

She also wants to figure out how to help astronauts’ faltering immune systems, which look older and have a harder time repairing tissue damage than they should after spending time in space. “The immune system is aging quite fast in microgravity,” Schrepfer says. She sends biological samples from young, healthy people on Earth up to orbit on tissue chips and tracks how they degrade.

Vision and bone problems are also among the more serious side effects. When astronauts spend a month or more in space, their eyeballs flatten, one aspect of a condition called spaceflight-associated neuro-ocular syndrome, which can cause long-lasting damage to eyesight. Bones and muscles are built for life on Earth, which involves the ever present pull of gravity. The work the body does against gravity to stay upright and move around keeps muscles from atrophying and stimulates bone growth. In space, without a force to push against, astronauts can experience bone loss that outpaces bone growth, and their muscles shrink. That’s why they must do hours of exercise every day, using specialized equipment that helps to simulate some of the forces their anatomy would feel on the ground—and even this training doesn’t fully alleviate the loss.

Perhaps the most significant concern about bodies in space, though, is radiation, something that is manageable for today’s astronauts flying in low-Earth orbit but would be a bigger deal for people traveling farther and for longer. Some of it comes from the sun, which spews naked protons that can damage DNA, particularly during solar storms. “[That] could make you very, very sick and give you acute radiation syndrome,” says Dorit Donoviel, a professor at the Baylor College of Medicine and director of the Translational Research Institute for Space Health (TRISH).

Then there are the big questions.

And an even simpler ethical question is, “Should we actually send people on these sorts of things?” Green says. Aside from incurring significant risks of cancer and overall body deterioration, astronauts aiming to settle another world have a sizable chance of losing their lives. Even if they do live, there are issues with what kind of an existence they might have. “It’s one thing just to survive,” Green says. “But it’s another thing to actually enjoy your life. Is Mars going to be the equivalent of torture?”

Yes.

Wow, it’s always nice to see a grand ethical question that can be answered so easily.

But is the pioneer way of life virtuous? I don’t think so. We have our own on-planet example of the American westward expansion, which was not at all about heroic, noble adventurers pushing back the foreskin of the wilderness. It was all about colonizers ripping up the environment, killing any people who stood in the way (at least we don’t have to worry about that in space), and suffering hellishly. I think you need to be a psychopath to want this way of life.

On this question, science-fiction scholar Gary Westfahl casts doubt on space travel’s inherent value. In his vast analyses of sci-fi, he has come to view the logic and drive of the enterprise as faulty. “I inevitably encountered the same argument: space travel represents humanity’s destiny,” he says of the impetus for writing his essay “The Case against Space.” Space explorers are often portrayed as braver and better than those who remain on their home planet: they’re the ones pushing civilization forward. “Philosophically, I objected to the proposition that explorers into unknown realms represented the best and brightest of humanity; that progress could be achieved only by boldly venturing into unknown territories,” Westfahl says. After all, a lot of smart and productive people (not to mention a lot of happy and stable people) don’t spend their lives on the lam. “Clearly, history demonstrates no correlation between travel and virtue,” he writes. “The history of our species powerfully suggests that progress will come from continued stable life on Earth, and that a vast new program of travel into space will lead to a new period of human stagnation,” he concludes ominously.

The article also talks about the Biosphere studies, which is a cartoon version of space exploration. It’s on Earth, so no peculiar gravity regimes or bombardments by radiation, and they’re swimming in plentiful air and water, so all they’re really testing is the human psychological response to prolonged isolation. It messes people up.

Kowalski’s talk at the Analog Astronaut Conference at Biosphere 2 was called “Only Eight Months.” The goal of those eight months was to study the medical and psychological effects of isolation. She and her teammates regularly provided blood, feces and skin samples so researchers could learn about their stress levels, metabolic function and immunological changes. Researchers also had them take psychological tests, sussing out their perception of time, changes in cognitive abilities and shifts in interpersonal interactions. Inside they had to eat like astronauts would, guzzling tubes of Sicilian pizza gel and burger gel. Kowalski would squeeze them into rehydrated soup to make meals heartier. Via their greenhouse, they got about a bowl of salad between the six of them every three weeks.

Kowalski missed freedom and food and friends, of course. But the real struggle came with her return to the real world once the isolation was over: “reentry, not to the atmosphere but to the planet,” she told the conference audience. She didn’t remember how to go about having friends, hobbies or a job and had trouble dealing with requests coming from lots of sources instead of just mission control. In the Q&A period after the talk, Tara Sweeney, a geologist in the audience, thanked Kowalski for talking about that part of the experience. Sweeney had just returned from a long stay in Antarctica and also didn’t quite know how to reintegrate into life in a more hospitable place. They had both missed “Earth,” the real world. But it was hard to come back.

These effects were reported at a conference of space enthusiasts. You can guess how they responded.

Still, the Analog Astronaut Conference crowd remained optimistic. “Where do we go from here?” conference founder and actual astronaut Sian Proctor asked at one point. On cue, the audience members pointed upward and said, “To the moon!”

I think maybe the real psychopaths aren’t the extreme loners who go out into the dangerous frontier, but the well-off people who send them there.

Your disappointingly vapid opinion piece is not going to encourage your book, Benjamin Oldroyd. There’s nothing there. I’m referring to an article titled Epigenetics and evolution: ‘the significant biological puzzle’ of sexual orientation. The author is plugging a new book, Beyond DNA, and is trying to persuade us that maybe he has an answer to why gay people exist by going through a couple of hypotheses.

The first hypothesis is that it is a product of kin selection.

Briefly, the kin selection idea is that a gene that promotes homosexual behaviour can spread in a population if homosexual people contribute significantly to the reproduction of close relatives. Although this idea is plausible, the lack of any genetic marker that is reliably associated with sexual orientation is a strong argument against it.

There is no such thing as a gay gene, though, so you can’t postulate the existence of one and build up an adaptive scenario around it. I agree with Oldroyd. It’s a useless hypothesis.

Another idea is that there are antagonistic alleles.

The “antagonistic alleles” idea is that there are certain genes that are selected in different directions, that is, positively selected in males, but negatively selected in females and vice versa. Hypothetically, because no such gene has been identified, a gene that promotes testosterone production could be at a selective advantage in males if it promoted traits such as muscle development, risk taking, opposite-sex sexual attraction and increased sexual attractiveness to females. But if the same gene were expressed in the same way in females it might be disadvantageous for reciprocal reasons. This means that selection could pull in different directions in males and females, maintaining different gene variants in a population. By that I mean, gene variants that have different selective advantages in males and females can potentially coexist in a population because neither is unambiguously better. If so, sexual orientation may be more fluid than one might expect based on biological sex alone. (Well, “der”, I suspect you are now thinking, but please don’t shoot your even-handed messenger.)

He explains it well, but…”might” and “could be” are not evidence. Again, this hypothesis falls apart because there is an absence of evidence for the existence of such alleles undergoing differential competition in males and females. It’s another adaptive just-so story. It’s a useless hypothesis.

Therefore, if you rule out two hypotheses, the third alternative must be the answer, right? Cue dramatic entrance of Intelligent Design…no wait, not that. Oldroyd knows better than that. But it’s the same rationale: we think we have evidence against the conventional alternatives, therefore that counts as evidence for a different hypothesis.

No, it does not. Now the magical mcguffin we’re all looking for is epigenetics.

The epigenetic hypothesis for the widespread occurrence of human homosexuality is based on the possibility of epigenetic inheritance of adjustments to a foetus’s testosterone sensitivity. Like most other epigenetic marks, sex-specific epigenetic marks are established anew in the early embryo following fertilisation.

Substituting hypothetical “epigenetic marks” for a hypothetical “gay gene” gets us nowhere unless you’ve got something concrete and specific. If you do, that would be very interesting…but epigenetics, by it’s nature, is fuzzy and hard to pin down. That is not to say that epigenetics is non-existent — it’s very real and important — but that you can’t slap a simple causal explanation on many complex phenomena, whether it’s a gene or a epigenetic marker.

My preferred explanation is also a bit fuzzy. We have to get beyond the bogus genetic determinism that appeals so strongly to naive minds, and epigenetic determinism would be just as bad. I think we have to accept that human behavior is sloppy and variable as hell. We are built by a long chain of probabilistic interactions, from molecules bouncing around in a messy cell, to a tangle of cells communicating chaotically with one another, to incompletely specified individuals that are shaped by interactions with a variable, changing environment to end up as people with mostly unpredictable characteristics. Physics and chemistry are biased by biological constraints, but the end result is not rigidly locked in by your genes — there is a messy cascade of genetic, epigenetic, and environmental interactions that is skewed by evolution to produce a generally viable outcome, but is tolerant of variability.

We have to abandon these mechanistic notions of a clockwork biology that spits out adults who were specified at conception by the chemistry of nucleic acids. It just doesn’t work that way. We are all products of stochastic processes.

My personal belief is that evolution has worked to take a population of apes and favor a hierarchy of properties that are all weakly specified, and we’re lucky if the majority of individuals conform to that hierarchy. First in priority is cooperation, building a social environment that promotes mutual aid (we all know how poorly that often works out). The way I look at it is that biology is telling us to love one another…and then it is far less fussy about the details. We don’t need a deterministic explanation for why individuals vary, it’s the nature of how they are built.