Lately, my genetics class has taken a turn, by intent. I start the semester with the basics: Mendel, simple crosses, learning the terminology, all of that simple stuff that most of them see as a review of high school biology. But then, once I’m reasonably confident they know the commonly understood rules, I start adding all the complications that Mendel knew nothing about, and then we start getting into epistasis and the complicated business of translating genotype into phenotype, and I essentially end up telling them that everything they learned before wasn’t exactly true, because real world heredity is a heck of a lot more complicated. You can’t usually reduce complex traits to one gene with alleles that are dominant or recessive.
So what do you know, the New Yorker comes out with an excellent article that highlights complexity and real world genetics: Runs in the Family, about the genetics of schizophrenia.
