MADS boxes, flower development, and evolution

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I’ve been writing a fair amount about early pattern formation in animals lately, so to do penance for my zoocentric bias, I thought I’d say a little bit about homeotic genes in plants. Homeotic genes are genes that, when mutated, can transform one body part into another—probably the best known example is antennapedia in Drosophila, which turns the fly’s antenna into a leg.

Plants also have homeotic genes, and here is a little review of flower anatomy to remind everyone of what ‘body parts’ we’re going to be talking about. The problem I’ll be pursuing is how four different, broadly defined regions of the flower develop, and what that tells us about their evolution.

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The eye as a contingent, diverse, complex product of evolutionary processes

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Ian Musgrave has just posted an excellent article on the poor design of the vertebrate eye compared to the cephalopod eye; it’s very thorough, and explains how the clumsy organization of the eye clearly indicates that it is the product of an evolutionary process rather than of any kind of intelligent design. A while back, Russ Fernald of Stanford University published a fine review of eye evolution that summarizes another part of the evolution argument: it’s not just that the eye has awkward ‘design’ features that are best explained by contingent and developmental processes, but that the diversity of eyes found in the animal kingdom share deep elements that link them together as the product of common descent. If all we had to go on was suboptimal design, one could argue for an Incompetent Designer who slapped together various eyes in different ways as an exercise in whimsy (strangely enough, though, this is not the kind of designer IDists want to propose)…but the diversity we do see reveals a notable historical pattern of constraint.

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The sea urchin genome

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Oh happy day, the Sea Urchin Genome Project has reached fruition with the publication of the full sequence in last week’s issue of Science. This news has been all over the web, I know, so I’m late in getting my two cents in, but hey, I had a busy weekend, and and I had to spend a fair amount of time actually reading the papers. They didn’t just publish one mega-paper, but they had a whole section on Strongylocentrotus purpuratus, with a genomics mega-paper and articles on ecology and paleogenomics and the immune system and the transcriptome, and even a big poster of highlights of sea urchin research (but strangely, very little on echinoderm development). It was a good soaking in echinodermiana.

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A summary of the MnCSE Science Education Saturday

My day was spent in the Twin Cities attending the inaugural public meeting of the Minnesota Citizens for Science Education (MnCSE), and I can safely say now that Science Education Saturday was a phenomenal success: a good turnout, two top-notch talks, a stimulating panel discussion, and an involved audience that asked lots of good questions. You should have been there! I expect that, with the good response we got today, that there will be future opportunities to attend MnCSE events.

I’ll just give a brief summary of the main points from the two talks today. I understand that outlines or perhaps even the powerpoint files will be available on the MnCSE page at some future date, but give the organizers a little time to recover from all the effort they put into this meeting.

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Granpappy was a Neandertal

Fascinating stuff…read this paper in PNAS, Evidence that the adaptive allele of the brain size gene microcephalin introgressed into Homo sapiens from an archaic Homo lineage, or this short summary, or John Hawks’ excellent explanation of the concepts, it’s all good. It’s strong evidence for selection in human ancestry for a gene, and just to make it especially provocative, it’s all about a gene known to be involved in brain growth, and it’s also showing evidence for interbreeding between Homo sapiens and Neandertal man.

The short short explanation: a population genetics study of a gene called microcephalin shows that a) it arose and spread through human populations starting about 37,000 years ago, b) this particular form of the gene (well, a small cluster of genes in a particular neighborhood) arose approximately 1.1 million years ago in a lineage distinct from that of modern humans, and c) the likeliest explanation for this difference is that that distinct lineage interbred with modern humans 37,000 years ago, passing on this particular gene variant that was then specifically selected for, a process called introgression.

The work looks sound to me, and I’m convinced. The one thing to watch for, though, is that there will be attempts to overreach and couple possession of this gene to some kind of intellectual superiority. We don’t know what this particular variant of the gene does yet! All we can say at this point is that some abstract data shows that a particular allele spread through the human population at a rate greater than chance would predict, that the gene itself has as one of its functions the regulation of brain growth, but that it is highly unlikely that that particular function is affected by the variant. Whatever it does, I expect the role is more along the lines of subtle fine-tuning rather than simply making people smart.

Strange worm, Xenoturbella

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This odd marine worm, Xenoturbella bocki, is in the news right now, and I had to look it up in Pechenik’s Biology of the Invertebrates(amzn/b&n/abe/pwll) to remind myself of what it was. Here’s the complete entry:

Xenoturbella bocki

This marine worm, first described in 1949 as an acoel flatworm and later claimed as either an early metazoan offshoot or a primitive deuterostome, has recently been affiliated with primitive bivalve molluscs, based upon a study of gamete development (oogenesis) and an analysis of sequence data from both 18S rRNA and mitochondrial genes. Little is known about its reproductive mode, and developmental studies that might help to resolve the phylogenetic issues are just starting to be reported. A second species was described in 1999.

The animals are up to 4 cm long, vermiform (worm-shaped), and covered by locomotory cilia. They have no digestive tract, and indeed no organs at all. Their only conspicuous morphological feature, other than their cilia, is a statocyst for determining orientation. To date, they have been collected only off the coasts of Sweden and Scotland, in sediments at depths of 20 m to 100 m.

That’s it. Part of that is now known to be wrong: the data showing an affinity to the molluscs is an artifact, caused by the fact that it somehow eats bivalves, and partly digested clam material contaminated the samples. Otherwise, not much is known; I’ve found papers describing the presence of oocytes inside the animal, but no one as far as I know has actually observed its development. It’s a strange, mysterious blob of a worm.

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A Devonian lamprey, Priscomyzon

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Reconstruction of Priscomyzon in dorsal (top) and left lateral (bottom) views. b, Macropthalmia stage of Lampetra showing anterior location of orbit and smaller oral disc, both positioned in front of the branchial region. The total length of the specimen is 116 mm. Drawings in a and b are scaled to show equivalent head lengths: from anterior limit of the oral disc to rear of the branchial region. Horizontal bars indicate the anterior–posterior span of the oral disc in each species.

The life of a parasite must be a good one, and often successful; the creature at the top of the drawing above is a primitive lamprey from the Devonian, 360 million years ago, and the similarities with the modern lamprey (at the bottom) are amazing. It’s less eel-like and more tadpole-like than modern forms, but it has the same disc-shaped mouth specialized for latching on to the flank of its host, it has similar circumoral teeth for rasping through scales and skin for its blood meal, the same pharyngeal adaptations for a life spent clamped to a fish.

I’ve put a photo of the fossil and a cladogram below the fold.

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A little pessimism about Extraterrestrial Intelligence

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Warren sent me link from The Indigestible, wondering if I was interested in these kinds of speculative questions about the existence of alien life. Why, yes I am…and even wrote something along the same lines a few years ago, coming to the same conclusions: I think intelligent extraterrestrials are unlikely.

My reasons are below the fold. Of course, I will retract my opinion immediately when Klaatu lands.

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