What I taught in the development lab today

After our disastrous chick lab — it turns out that getting fertilized chicken eggs shipped to remote Morris, Minnesota during a blizzard is a formula for generating dead embryos — the final developmental biology lab for the semester is an easy one. I lectured the students on structuralism and how there are more to cells then genes (there’s also cytoplasm and membranes and environment) earlier today. This afternnon I’ve given them recipes for soap bubble solution and told them to play. They’re supposedly making little model multicellular organisms by chaining soap bubbles together, and observing how the membranes follow rules of organization just like the ones we see in living tissue.

In case you’re wondering what the recipe is so you can do it too, here’s my bubble soap formula:

  • 5ml Dawn dishwashing soap

  • 100ml DI water

  • 1ml glycerine

It gets better as it ages — there are perfumes and a small amount of alcohol solvent in the dishwashing liquid which evaporate off with time. The students are playing with concentrations, and if you’re making it up fresh and don’t want to wait until tomorrow, you can increase the concentrations of soap and glycerine.

The more glycerine you add, the more long-lasting the bubbles are…and unfortunately, the heavier they are. If you want bubbles that will waft gently on the breeze, you’ll want less glycerine. It’s a very forgiving recipe, just play.

I’ve also provided the students with a couple of books: the classic Soap Bubbles: Their Colors and Forces Which Mold Them by C.V. Boys, and The Science of Soap Films and Soap Bubbles by Cyril Isenberg. They’re more about math and physics, but they have some nice illustrations. These are projects you can do at home with cheap ingredients bought at the grocery store, so those of you with kids might try playing with it this summer. There are simple rules about the angles of intersection between bubbles — if you’re mathematically inclined, take pictures and use a protractor and see if you can work them out. There’s also some really cool stuff going on with colors, since the bubbles have a gradient of thickness from top to bottom and you get wonderful colors caused by refraction and reflection and phase shifts across the membrane.

OK, if you don’t have kids, you have my permission to play with soap bubbles, too. Tell everyone who looks at you funny that you’re doing Science!

What I taught today: a send-off with an assignment

Today was the last day I lecture at my developmental biology students. We have one more lab and one final class hour which will be all about assessment, but this was my last chance to pontificate at them…so I told them about all the things I didn’t teach them, and gave them a reading list for the summer. (I know, there’s no way they’re going to take these to the beach, but maybe when they move on in their careers they’ll remember that little reference in their notes and look it up.)

So here are the books I told them to go read.

We’ve been all up in the evo-devo house this semester, so I urged them to read the antidote, just to get some perspective. This is the great big book all the grown-up developmental biologists read and admire and regard as gloriously wrong in many ways, but still an important reminder that physical and chemical properties of whole cells and organisms matter — it’s not all genes. And of course that legendary book is On Growth and Form by D’Arcy Wentworth Thompson. I tell all my students that if ever they want to get serious about developmental biology, they must read Thompson.

For the more modern gang who like computers and math and logic puzzles, I point them at At Home in the Universe: The Search for the Laws of Self-Organization and Complexity and The Origins of Order: Self-Organization and Selection in Evolution by Stuart A. Kauffman. He’d really benefit from more time in a wet lab, but still, there’s some very provocative stuff in those books about how complexity can spontaneously arise. I also gave them a bit of an introduction to NK network theory.

There is always a philosopher or two in the class, so for them I suggest that they read The Ontogeny of Information: Developmental Systems and Evolution by Susan Oyama. Developmental Systems Theory suffers for its lack of applicability — it really is a little too abstract for most scientists — but I love it for its more holistic approach to development.

For the hardcore biologists, the ones who are ready to read a book where every page makes them think very hard, I suggest Developmental Plasticity and Evolution by Mary Jane West-Eberhard. It’s quite possibly the most brilliant book I’ve ever read, but it’s dense and challenging. Intentionally challenging: she really does question a lot of the dogma of evolutionary and developmental biology, and forces you to realize there are a lot of wide-open, intensely interesting questions out there.

And finally, I brought up a book I seriously think about making the class text every year, Ecological Developmental Biology by Scott F. Gilbert and David Epel. The course as it is now is a fairly traditional modern molecular genetics and development class, with a solid overlay of evolutionary biology. The Gilbert and Epel book integrates all that with ecology — and I firmly believe that the well-rounded biologist of the type a liberal arts university tries to generate ought to have a balanced conceptual understanding of ecology, development, and evolution.

That’s the short list. It’s too bad I don’t have total control of my students’ lives, or I’d have them studying ten or twenty books over the summer. Or they probably think it’s a good thing I don’t.

Fortunately for Matt Yglesias, Lindsay Beyerstein only leaves him in a metaphorical smoking crater.

A couple of commenters here have persisted in defending Matthew Yglesias’ odious bleat that life is cheaper in Bangladesh because it ought to be because reasons, and that any anger we Westerners might feel about the horrendous loss of life in the recent factory collapse ought more helpfully be directed to buying clothes made in those collapsing sweatshops so that eventually the people making a few hundred dollars a year will have flat screen televisions just like us.

Yglesias is doubling down. In a followup post, he stands by his conclusion that poor countries need to have less stringent workplace safety standards, and adds, as a prelude to accusing his critics of “poisoning the atmosphere,” [see update at end of post]

I’m not really sure what Americans can constructively do to get better enforcement of building codes in Bangladesh

As it turns out, Lindsay Beyerstein has a possible answer:

A group of Bangladeshi and international trade unionists put forward a bold plan to make the garment industry in Bangladesh safer. A surcharge of 10 cents per garment over 5 years would raise $600 million a year, enough to radically transform the infrastructure of the garment industry in Bangladesh. Walmart and the Gap rejected the proposal in 2011.

So that’s pretty handy: All America has to do to make sweatshops in Bangladesh safer is to stop fucking obstructing their being made safer. It’s win-win!

Oh, and a protip to Yglesias: If you persist in discussing the worker safety aspects of US investment in South Asia, you might want to consider not using “poisoning the atmosphere” as a way to tone-troll your critics. We have a 30th Anniversary coming up late next year that will turn that phrase a bit unfortunate.

Updated: in comments, nialscorva correctly points out that I misread Yglesias’ reference to “poisoning the atmosphere.”  My bad. Leaving the post as it was for transparency’s sake.

Bruce Alberts, failure

This is not a very exciting video, but I might just inflict it on my cell biology students in the fall. We got a fair amount of flak from students last time around who were frustrated when labs didn’t work like a recipe from a cookbook — yet that’s how science usually proceeds, with lots of tinkering and frustration and repetition.

I also like his point about how teaching is important for science (although the students won’t really care about that.) I don’t think I really got the breadth of my discipline until I had to master it in order to teach it — there’s nothing quite like the panic behind “I’ve got to lecture for an hour on vesicle transport tomorrow!” to focus the mind wonderfully on a subject you might have found of only passing interest previously.

(via Sandwalk.)

It’s another exam day!

I’ve been terrible about updating everyone about my class the last few weeks — we’re coming up on the end of the semester, so I’ve been going a little bit mad. We’ve been focusing on vertebrate development lately, and right now we’ve got a few dozen fertilized chicken eggs sitting in an incubator and developing embryos. Maybe. It is always a real pain to get these things delivered to remote Morris, Minnesota — I delayed this part of the lab to the very end of the semester, hoping the sun would emerge and warm the hemisphere enough that when UPS took their sweet time getting them to me, they wouldn’t freeze in the back of the truck. As usual, though, next day delivery turned into two day delivery, and we haven’t seen Spring yet. So we’ll soon know whether they survived their harrowing journey through the frigid Northlands, and if they haven’t, I’ll have to throw up my hands and cry.

Or I could torture my students to ease my frustration. Yeah, that’s the ticket. So it’s exam day.

Developmental Biology Exam #3

This is a take-home exam. You are free and even encouraged to discuss these questions with your fellow students, but please write your answers independently — I want to hear your voice in your essays. Also note that you are UMM students, and so I have the highest expectations for the quality of your writing, and I will be grading you on grammar and spelling and clarity of expression as well as the content of your essays and your understanding of the concepts.

Answer two of the following three questions, 500-1000 words each. Do not retype the questions into your essay; if I can’t tell which one you’re answering from the story you’re telling, you’re doing it wrong. Include a word count in the top right corner of each of the two essays, and your name in the top left corner of each page. This assignment is due in class on Monday, and there will be a penalty for late submissions.

Question 1: One of Sarah Palin’s notorious gaffes was her dismissal of “fruit fly research” — she thought it was absurd that the government actually funded science on flies. How would you explain to a congressman that basic research is important? I’m going to put two constraints on your answer: 1) It has to be comprehensible to Michele Bachmann, and 2) don’t take the shortcut of promising that which you may not deliver. That is, no “maybe it will cure cancer!” claims, but focus instead on why we should appreciate deeper knowledge of biology.

Question 2: There is an interesting tension in evo devo: on the one hand, we like to talk about the universality of molecular mechanisms, but on the other hand, we’re also very interested in the differences, both in phenotype and genetics. This is an old debate in evolutionary theory, too, so it’s not unique to development, but how do you reconcile unity and diversity simultaneously?

Question 3: When I told you about axis specification in Drosophila, the story was relatively straightforward: maternal factors switch on a chain of zygotic genes that set up the pattern. When I told you about the same process in vertebrates, though, I didn’t give you the same level of detail—I gave you buckets of transcription factors and said they had various roles. Dig deeper. Pick ONE of these vertebrate dorsalizing factors out of the bucket and tell me more about it: noggin, chordin, frizbee, goosecoid, pintallavis.

I have to disagree with Jerry Coyne

Ball State University has a crap course on their curriculum: they have a crank professor, Eric Hedin, who is pushing religion and creationism in the guise of an astronomy course. It’s bad science and bad teaching, and I think Coyne has adequately document the abysmal quality of the material. It’s all religious apologetics and intelligent design creationism. I’m not going to disagree with that at all, and Ball State ought to be acutely embarrassed.

Unfortunately, this part of Coyne’s disagreement is invalid.

This has to stop, for Hedin’s course, and the University’s defense of it, violate the separation of church and state mandated by the First Amendment to the U.S. Constitution (“freedom of religion”) and which has been so interpreted by the courts. It’s religion taught as science in a public university, and it’s not only wrong but illegal.  I have tried approaching the University administration, and have been rebuffed.

This will now go to the lawyers.

No, sorry, not right — academic freedom is the issue here, and professors have to have the right to teach unpopular, controversial issues, even from an ignorant perspective. The first amendment does not apply; this is not a course students are required to take, and it’s at a university, which students are not required to attend. It’s completely different from a public primary or secondary school. A bad course is an ethical problem, not a legal one. It’s also an issue that the university has to handle internally.

This kind of thing happens. I’ve known of a couple of cases where faculty go ’round the bend and start flaking out in the classroom, and there’s not much you can do, except what Ball State seems to be doing. Put the person into low level service courses where they have to teach students something basic, like algebra, where their weird views can’t do much harm. Or give them some non-majors elective where they aren’t going to have much influence. I notice in Hedin’s courses that he’s only teaching low level courses and honors/interdisciplinary courses. It looks like maybe the department is doing their best to isolate a problem.

Another option is to take this history into consideration in tenure decisions. Hedin is an assistant professor, and so is probably untenured — the department may be avoiding confrontation until it gets dealt with decisively in Hedin’s tenure year.

If you’ve got a tenured professor who has gone weird on you, it’s a bigger problem…then you’ve got damage that needs to be routed around. Check out Michael Behe’s class schedule at Lehigh, for instance. It looks to me like they’ve carefully placed him only in courses where his ignorance about evolution won’t hurt too much. Are we going to sue Lehigh to get him fired? That won’t work, and is also an insult to a department that is doing their best with a bit of deadwood.

I think it’s very unwise for an atheist professor to pursue legal action against another professor for their religious views. That’s a two-edged sword, and if a university were to cave to public pressure to fire a professor for unpopular views, you know who’d be next.

Now it is possible that the whole physics department at Ball State is full of credulous nitwits who are trying to build a theological perspective into their curriculum. That will be corrected in two ways: they’re going to have a more difficult time hiring good faculty, and as the reputation of their department spreads, they’re going to have a more difficult time recruiting good students. Rot expands, you know. It’s not a good thing to encourage.

But it’s probably premature to threaten a department with legal action for having one dingbat assistant professor.

(via Larry Moran)

My ulterior motive

In case you’re wondering why I’m experimenting with video, there actually is an ulterior motive, and it’s the same one that got me into blogging in the first place: teaching. I’m teaching science at an undergraduate institution, and contrary to many people’s expectations, a bachelor’s degree does not confer a deep understanding of science, and it can’t. Students come out of high school with an ability to read and do basic math (at least the ones we admit to college!), and have wildly varying abilities in writing, analysis, and thinking. I think the undergraduate university’s role is more to deepen the student’s abilities in those general skills, and also to provide a broad knowledge base in a discipline of their choosing. We’re preparing students to go off and do science, if that’s what they want to do. I’ve done my job if my students go to graduate school competent and confident, ready to get to work and explore the natural world. Or if they choose not to follow a science career, they’re open to read and think about the world in a scientific way.

So there are a couple of things I do in my upper level lab courses. I take a hands-off approach: I teach students how to use the tools in my lab, give them a general idea of what would be cool to do or see, and turn them loose. If I see a combination of frustration (“I can’t get it to work! How do I get it to work?”) and play (“What if we do this?”), it’s a success. I have them blogging because it’s a sneaky way to get them to think about the subject of the class outside of class, and also to get them to blend their interests — which usually aren’t identical to mine! — with what I’m teaching.

And then there are presentations. Communicating your work is an important part of doing science, too. I try to get them to do that with the blogging, but also our university promotes a capstone experience, our senior seminars. Before a student can graduate, they have to do a one hour talk on some subject in their discipline, and it’s a big deal/ordeal to the students, and also a big deal/ordeal for us faculty in one of the largest majors on campus. Their quality varies all over the place, even though many of my colleagues and I do incorporate requirements for giving in-class presentations in our upper level courses, and we have a preparatory course on writing that includes giving presentations. There’s a limitation on doing that in class, though: you’ve got 20 students, you can’t chew up multiple class hours getting them all to do rehearsals and rehearsals under your supervision. We usually get an abstract and a promise and a conversation with them to help explain the data, and then boom, they do their talk to the class. It’s one shot and they’re done. That’s not the way to learn.

So I’ve had this idea…this is a generation that’s comfortable with their camera phones, that whiles away hours on facebook and youtube. What if I tried to combine that with doing presentations? What if, in one of my lab courses, I made the final project to be producing a short youtube video explaining some piece of data that they’d gotten in the lab? Put a micrograph or a chart or a time-lapse video on the screen and explain it with a voice-over, or stand in front of a camera while discussing some fine point of theory, or make a how-to video on how to use the microscope. It’s something they could tweak until it looks good, I’d be able to review work in progress fairly easily, and then what they put up for final evaluation might be a little more polished. This would be a useful skill for the future. I’m also rather impressed with how Casey Dunn has his students make creature features.

One catch: to have the students do it, I have to be able to do it. So in my spare time (hah!), I’ve been tinkering with ideas. I got some clamp lamps to play with lighting, I’ve got some cheap and simple backdrops to play with, I read Steve Stockman’s How to Shoot Video That Doesn’t Suck (which has a lot of damn good basic practical advice), and I’ve been doing some experimenting, most of which will never see the light of day. I’m learning stuff, which is always fun.

And it’s useful stuff, too. For instance, I’m a words and typing sort of guy, so my approach so far has been to write a script and then wrap video and images around it. That doesn’t work so well. I’m slowly learning that in this medium you start with video and images and wrap words around them. And that’s exactly what we do routinely in a science talk! You’ve got these chunks of data in the form of images and numbers, and what you do in a presentation is show them and add your verbal explanation on top. Man, I ought to know this stuff already. I just have to adapt.

So this summer you might be seeing more of my unphotogenic face in videos as I clumsily try to get some basic skills in this medium. The payoff, though, is that in a year or so I’ll be able to teach my students how to do it better, and then we’ll get a fine new crop of video stars who are comfortable explaining science in front of a camera.

But don’t worry, you don’t have to suffer through my struggles, just don’t watch me.

It’s Matthew Yglesias’ world: we just get blown up in it.

I haven’t had much use for The Lizard of K Street since he posted this sociopathic little gem in 2004:

Did the president really gut the Endangered Species Act yesterday while no one was paying attention? So I’ve heard, at any rate. If so, good riddance. You’ll all yell at me, I suppose, but really: Who cares? Species die, shit happens, get over it.

It is not exactly news that Matthew Yglesias is a tepid thinker. Poking holes in Yglesias’ vacuous, self-absorbed puffery has long been a popular pastime among bloggers from the progressive left to the hard right. He’s got himself a cushy gig these days, squirting out incontinent posts with no detectable logical or factual value, and as long as people give his outlets page views it’s all good. Eyeballs are eyeballs, and it doesn’t matter much if those eyeballs are rolling upward hard enough to burst blood vessels.

But this shit? This shit is inexcusable.

Bangladesh may or may not need tougher workplace safety rules, but it’s entirely appropriate for Bangladesh to have different—and, indeed, lower—workplace safety standards than the United States.

The reason is that while having a safe job is good, money is also good. Jobs that are unusually dangerous—in the contemporary United States that’s primarily fishing, logging, and trucking—pay a premium over other working-class occupations precisely because people are reluctant to risk death or maiming at work. And in a free society it’s good that different people are able to make different choices on the risk–reward spectrum.…

Bangladesh is a lot poorer than the United States, and there are very good reasons for Bangladeshi people to make different choices in this regard than Americans. That’s true whether you’re talking about an individual calculus or a collective calculus. Safety rules that are appropriate for the United States would be unnecessarily immiserating in much poorer Bangladesh. Rules that are appropriate in Bangladesh would be far too flimsy for the richer and more risk-averse United States. Split the difference and you’ll get rules that are appropriate for nobody.

There are three main problems with Yglesias’ argument.

  1. Yglesias’ argument is profoundly immoral. People are willing to take bigger risks to feed their families when they’re burdened by poverty, yes. But arguing that we should use that unfortunate fact as a basic design feature of global workplace safety regulations is vile.
  2. Yglesias’ argument is profoundly ahistorical as well. Workplace safety regulations — and environmental laws, and education for women, and all of the thousands of other social goods we fight for — don’t magically appear when societies’ wealth passes a certain threshold as a result of the airy  fapping of the invisible hand. Those regulations come into being because people fight for them, often dying in the process, against the opposition of the entrenched powers that make the regulations necessary in the first place.  And here Yglesias is on the side of the entrenched powers, willing to wave away yet another workplace disaster so that he can continue to enjoy the cheap cotton shorts, running shoes, and tablet computers he sees as his birthright.
  3. Yglesias’ argument is essentially plagiarized from a 1991 memo by Laurence Summers written when the latter was the chief economist at the World Bank. A salient sampling from that memo:

I’ve always thought that under-populated countries in Africa are vastly UNDER-polluted, their air quality is probably vastly inefficiently low compared to Los Angeles or Mexico City. … The concern over an agent that causes a one in a million change in the odds of prostrate[sic] cancer is obviously going to be much higher in a country where people survive to get prostrate[sic] cancer than in a country where under 5 mortality is 200 per thousand.

An individual human life is worth fewer U.S. dollars in Bangladesh, and so betting that lower-value life against the possibility that you might actually survive your $432 per annum minimum wage job just makes better sense there than it does here, eh Matt? Hell, if the typical Bengali minimum wage worker survives his or her job for three or four years before they get crushed to death by an unsafe building, they may actually have come out well ahead of the game!

It’s a repugnant argument.

Matthew Yglesias should be ashamed of himself.

Christina Amphlett has died

If you were ever into 80s pop, you’d know Christina Amphlett, the lead singer of the Australian band, the Divinyls. She’s had some rough years since, dealing with breast cancer and multiple sclerosis, which finally did her in this past weekend, at the too-young age of 53. (Cancer sucks, and so do progressive neurological disorders, and she suffered through both.)

Americans mainly know her for just one song, “I Touch Myself,” but she actually did a number of successful albums in her own country, so I thought rather than playing the most obvious one, I’d put up a different song.