Acoelomorph flatworms and precambrian evolution

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One of many open questions in evolution is the nature of bilaterian origins—when the first bilaterally symmetrical common ancestor (the Last Common Bilaterian, or LCB) to all of us mammals and insects and molluscs and polychaetes and so forth arose, and what it looked like. We know it had to have been small, soft, and wormlike, and that it lived over 600 million years ago, but unfortunately, it wasn’t the kind of beast likely to be preserved in fossil deposits.

We do have a tool to help us get a glimpse of it, though: the analysis of extant organisms, searching for those common features that are likely to have been present in that first bilaterian; we’re looking for the Last Common Bilaterian by finding the Least Common Denominators among living species. And one place to look is among the flatworms.

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Deep homologies in the pharyngeal arches

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PvM at the Panda’s Thumb has already written a bit about this issue in the article “Human Gland Probably Evolved From Gills”, but I’m not going to let the fact that I’m late to the party stop me from having fun with it. This is just such a darned pretty story that reveals how deeply vertebrate similarities run, using multiple lines of evidence.

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Polar lobes and trefoil embryos in the Precambrian

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The diagram above shows the early cleavages of the embryo of the scaphopod mollusc, Dentalium. You may notice a few peculiarities: the first cleavage is asymmetric, producing a cell called AB and a larger sister cell, CD. Before the second division, CD makes a large bulge, called a polar lobe, and it almost looks like it’s a three-cell stage—this is called a trefoil embryo, and can look a bit like Mickey Mouse. The second division produces an A, a B, a C, and a D cell, and there’s that polar lobe, about as large as the regular cells, so that it now resembles a 5-cell embryo. What’s going on in these animals?

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Maternal effect genes

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Maternal effect genes are a special class of genes that have their effect in the reproductive organs of the mutant; they are interesting because the mutant organism may appear phenotypically normal, and it is the progeny that express detectable differences, and they do so whether the progeny have inherited the mutant gene or not. That sounds a little confusing, but it really isn’t that complex. I’ll explain it using one canonical example of a maternal effect gene, bicoid.

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Pufferfish and ancestral genomes

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The fugu is a famous fish, at least as a Japanese sushi dish containing a potentially lethal neurotoxin that was featured on an episode of The Simpsons. Fugu is a member of the pufferfish group, which have another claim to fame: an extremely small genome, roughly a tenth the size of that of other vertebrates. The genome of several species of pufferfish is being sequenced, and the latest issue of Nature announces the completion of a draft sequence for the green spotted pufferfish, Tetraodon nigroviridis, a small freshwater species.

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How to evolve a vulva

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Creationists are fond of the “it can’t happen” argument: they like to point to things like the complexity of the eye or intricate cell lineages and invent bogus rules like “irreducible complexity” so they can claim evolution is impossible. In particular, it’s easy for them to take any single organism in isolation and go oooh, aaah over its elaborate detail, and then segue into the argument from personal incredulity.

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Modules and the promise of the evo-devo research program

Since Evolgen recognizes the importance of evo-devo, I’ll return the favor: bioinformatics is going to be critical to the evo-devo research program, which to date has emphasized the “devo” part with much work on model systems, but is going to put increasing demands on comparative molecular information from genomics and bioinformatics to fulfill the promise of the “evo” part. I’m sitting on a plane flying east, and to pass the time I’ve been reading a very nice review of the concept of modularity in evo-devo by Paula Mabee (also a fish developmental biologist, and also working in a small college in a small town in the midwest…but rather deservedly better known than yours truly). In addition to summarizing the importance of the concept of modularity to evolution and development, the paper also does something I always appreciate: it summarizes the key questions that the modern evo-devo research program is working to answer.

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Evo-devo wars

Fellow scienceblogger Evolgen has seen the light—evo-devo is wonderful. He’s attending a meeting and listening to some of the bigwigs in the field talk about their work, in particular some research on the evolution of gene regulation. While noting that this is clearly important stuff, he also mentions some of the bickering going on about the relative importance of changes in cis regulatory elements (CREs) vs. trans acting elements, transcription factors. I’ve got a longer write-up of the subject, but if you don’t want to read all of that, the issue is about where the cool stuff in the evolution of morphology is going on. Transcription factors are gene products that bind to regulatory regions of other genes, and change their pattern of expression. The things they bind to are the CREs, which are non-coding regions of DNA associated with particular genes.

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Is there a teratologist in the house?

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Call me perverse, but my first thought on seeing this kid was that I desperately want to see an x-ray of the pectoral girdle. It looks to me from this one picture that the lower arm must lack a scapula or a clavicle, or at best have fragments with screwy and probably nonfunctional connections. I don’t understand why the doctors are even arguing about which arm could be more functional, if the article is correct. Or why they’re even considering it important to lop one off: if there aren’t circulatory defects or it isn’t impairing the function of the ‘best’ arm, why take a knife to him?

Poor kid. It does look like a very weird and fascinating developmental aberration, though, and it sounds like there are other internal asymmetries that are going to make life rough for him.

Chelifores, chelicerae, and invertebrate evolution

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One of the most evocative creatures of the Cambrian is Anomalocaris, an arthropod with a pair of prominent, articulated appendages at the front of its head. Those things are called great appendages, and they were thought to be unique to certain groups of arthropods that are now extinct. A while back, I reported on a study of pycnogonids, the sea spiders, that appeared to show that that might not be the case: on the basis of neural organization and innervation, that study showed that the way pycnogonid chelifores (a pair of large, fang-like structures at the front of the head) were innervated suggested that they were homologous to great appendages. I thought that was pretty darned cool; a relic of a grand Cambrian clade was swimming around in our modern oceans.

However, a new report by Jager et al. suggests that that interpretation may be flawed, and that sea spider chelifores are actually homologous to the chelicerae of spiders.

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