Step away from that ladder

We’ve often heard this claim from creationists: “there is no way for genetics to cause an increase in complexity without a designer!”. A recent example has been Michael Egnor’s obtuse caterwauling about it. We, including myself, usually respond in the same way: of course it can. And then we list examples of observations that support the obviously true conclusion that you can get increases in genetic information over time: we talk about gene duplication, gene families, pseudogenes, etc., all well-documented manifestations of natural processes that increase the genetic content of the organism. It happens, it’s clear and simple, get over it, creationists.

Maybe we’ve been missing the point all along, though. The premise of that question from the creationists is what they consider a self-evident fact: that evolution posits a steady increase in complexity from bacteria to Homo sapiens, the deep-rooted idea of the scala natura, a ladder of complexity from simple to complex. Their argument is that the ladder cannot be climbed, and our response is usually, “sure it can, watch!” when perhaps a better answer, one that is even more damaging to their ideology, is that there is no ladder to climb.

That’s a tougher answer to explain, though, and what makes it even more difficult is that there is a long scientific tradition of pretending the ladder is there. Larry Moran has an excellent article on this problem (Alex has a different perspective), and I want to expand on it a little more.

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Ascidian evo-devo

Here are three animals. If you had to classify them on the basis of this superficial glimpse, which two would you guess were most closely related to each other, and which one would be most distant from the others?

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On the left is a urochordate, an ascidian, a sessile, filter-feeding blob that is anchored to rocks or pilings and sucks in sea water to extract microorganismal meals. In the middle is a cephalochordate, Amphioxus, also a filter feeder, but capable of free swimming. On the right are some fish larvae. All are members of the chordata, the deuterostomes with notochords. If you’d asked me some years ago, I would have said it’s obvious: vertebrates must be more closely related to the cephalochordates—they have such similar post-cranial anatomies—while the urochordates are the weirdos, the most distant cousins of the group. Recent developments in molecular phylogenies, though, strongly suggest that appearances are deceiving and we vertebrates are more closely related to the urochordates than to the cephalochordates, implying that some interesting evolutionary phenomena must have been going on in the urochordates. We’d expect to see some conservation of developmental mechanisms because of their common ancestry, but the radical reorganization of their morphology suggests that there ought also be some significant divergence at a deep level. That makes the urochordates a particularly interesting group to examine.

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No rest for the wicked

Didn’t I just say “Woo hoo” yesterday? False alarm. Scarcely do I clear one set of major tasks away than another set rise up. I already mentioned that I was going to be the speaker at the Humanists of Minnesota banquet on Saturday evening. I neglected to tell you all that I’m leaving for the University of Michigan tomorrow to give the keynote at the Genetic Programming Theory and Practice Workshop.

I know virtually nothing about genetic programming, so this is a wonderful opportunity to learn something about it.

Since I’m certainly not going to be able to tell them a thing about genetic programming, I’m planning to tell them a little about my own skewed perspective as one of those metazoan-centric fans of developmental processes. I’m hoping they might learn a little something from me, and that we’ll all have some fun with ideas about embryos. Here’s my very brief abstract:

A developmental biologist’s view of evolution

The ongoing integration of molecular genetics, developmental biology, and evolution (the field of evo-devo) is stirring up new ideas and new questions. I will tell a few stories from the evo-devo literature that illustrate the importance of the principles of developmental plasticity and developmental constraint on evolutionary trajectories — showing that these are two competing and complementary forces operating on multicellular organisms. My argument is that the contingencies of developmental architectures may well be as significant a force on evolutionary histories as selection.

Next week I get to slack off. No, wait, there’s also…

Sperm in action

This is a beautifully done movie, although it does get a bit silly in the end.

One point this brought to mind: have you ever looked at sperm? They’re amazing. We humans do go through a single-celled haploid stage which is the focus of some very intense selection pressure, and humans in their haploid phase possess some impressive abilities. No brains, but the sperm are motile and exhibit seeking behavior. Eggs are also wonderful — they are precisely balanced on the edge of criticality, ready to erupt into a cascade of changes with a single stimulus. It’s easy to dismiss gametes as blobs and slime, but they have all the charm and complexity of bacteria … and I say that completely non-ironically.

(via Street Anatomy)

We have the brains of worms

Way back in the early 19th century, Geoffroy St. Hilaire argued for a radical idea, that vertebrates and most invertebrates were inverted copies of each other. Vertebrates have a dorsal nerve cord and ventral heart, while an insect has a ventral nerve cord and dorsal heart. Could it be that there was a common plan, and that one difference is simply that one is upside down relative to the other? It was an interesting idea, but it didn’t hold up at the time; critics could just enumerate the multitude of differences observable between arthropods and vertebrates and drown out an apparent similarity in a flood of documented differences. Picking out a few superficial similarities and proposing that something just looks like it ought to be so is not a persuasive argument in science.

Something has changed in the almost 200 years since Geoffroy made his suggestion, though: there has been a new flood of molecular data that shows that Geoffroy was right. We’re finding that all animals seem to use the same early molecular signals to define the orientation of the body axis, and that the dorsal-ventral axis is defined by a molecule in the Bmp (Bone Morphogenetic Protein) family. In vertebrates, Bmp is high in concentration along the ventral side of the embryo, opposite the developing nervous system. In arthropods, Bmp (the homolog in insects is called decapentaplegic, or dpp) is high on the dorsal side, which is still opposite the nervous system. At this point, the question of whether the dorsal-ventral axis of the vertebrate and invertebrate body plans have a common origin and whether one is inverted relative to the other has been settled, and the answer is yes.

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Hagfish embryos!

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A hagfish egg with a 14.3-mm pharyngula-stage embryo inside (arrows). Scale bar, 5 mm.

I’ve been looking forward to seeing these little jewels in print since I saw Kuratani talk about them at the SICB meetings in January. Hagfish are wonderfully slimy jawless chordates that have been difficult to raise in the lab—although if you poke a whale corpse rotting in the cold deeps you’ll find them swarming everywhere. The Kuratani lab has managed to keep animals of the species Eptatretus burgeri alive and healthy in a lab aquarium maintained at cold temperatures (16°C), and has even had success in breeding them. That object to the right is a single hagfish egg, brown and leathery-shelled and surprisingly big—it’s an inch and a half long!

They collected 92 eggs, and then another limitation emerged: it took 5-7 months for embryos to develop in a small number of the eggs. Hagfish aren’t going to be your typical fast-developing model system, I’m afraid, but they are extraordinarily cool animals, and it’s good to see work beginning on them.

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Wells’ flagrantly false commentary on Hox complex structure

This evening, I am watching an episode of that marvelous and profane Western, Deadwood, as I type this; it is a most excellently compensatory distraction, allowing me to sublimate my urge to express myself in uncompromisingly vulgar terms on Pharyngula. This is an essential coping mechanism.

I have been reading Jonathan Wells again.

If you’re familiar with Wells and with Deadwood, you know what I mean. You’ll just have to imagine that I am Al Swearingen, the brutal bar-owner who uses obscenities as if they were lyric poetry, while Wells is E.B. Farnum, the unctuous rodent who earns the contempt of every man who meets him. That imagination will have to hold you, because I’m going to restrain myself a bit; I’m afraid Wells would earn every earthy sobriquet I could imagine, but I’ll confine myself to the facts. They’re enough. The man completely misrepresents the results of a paper and a whole discipline, and does it baldly on the web, as if he doesn’t care that his dishonesty and ignorance leave a greasy, reeking trail behind him.

Let’s start with Wells’ own words.

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Those disreputable evo-deviants and their bigotry against the single-celled

I must disagree with Larry Moran, who accuses the field of evo-devo of animal chauvinism — not that it isn’t more or less true that we do tend to focus on metazoans, but I disagree with an implication that this is a bad thing or that it is a barrier to respectability. Larry says we need to cover the other four kingdoms of life in greater breadth, which I agree is a fine idea. I would like to have a complete description of the genome of every species on earth, a thorough catalog of every epistatic interaction between those genes during development, a hundred labs working on each species, and a massive collection of papers for each one documenting every step and every protein and every variation in their development. I would like it tomorrow.

I think we all agree that that would be impractical. The question is how we will focus our research to maximize our use of limited resources, and get us useful answers that will lead us in productive directions. Larry is advocating maximizing our phyletic breadth by following organisms representative of the greatest amount of diversity. He is proposing this in opposition to the proposal from Jenner and Wills, who suggest a different strategy — and I find myself agreeing more with Jenner and Wills than with Moran.

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