I know this is a horrible photo — I just snapped a picture of the journal hardcopy, which I own, instead of grabbing a PDF from the web, because it’s from 1985 and I’d have to pay to get a copy of my own paper — but this is what I was doing in grad school. I started as somebody who was interested in neurons and the nervous system, so what you’re seeing is a transverse section of the spinal cord of a zebrafish, with a couple of motoneurons labeled black with a tracer enzyme. I spent most of my time teasing apart how those cells grew and made connections.
But all the while there was this one prominent feature of the animal that kept trying to distract me. See that big clear white space below the spinal cord? That’s the notochord. It’s huge, a long transparent cylinder built like a stack of glass coins, running from the neighborhood of the hindbrain all the way back to the tip of the tail. The image from Stemple below is much clearer, since the notochord has been painted pink.
Its superficial function is obvious: it’s a springy rod that the muscles of the fish’s body act upon for swimming and escape behaviors. While I was just doing neural circuitry work, that was sufficient — it’s part of the motor apparatus. Neurons make muscles twitch which flexes the notochord and generates the back and forth motion that propels the animal through the water. Case solved.








