Mary Schweitzer and the mysterious dinosaur soft tissue

Science has an overview of Schweitzer’s work. You may recall that she published descriptions of cells and soft tissue imbedded deep in fossilized dinosaur bone. That work is much beloved by creationists (it means those bones must be young, they say), but despite starting out as a creationist, she does not support that claim of a young age. She’s a theistic evolutionist.

She went back to school at Montana State University in Bozeman for an education degree, planning to become a high school science teacher. But then she sat in on a dinosaur lecture given by Jack Horner, now retired from the university, who was the model for the paleontologist in the original Jurassic Park movie. After the talk, Schweitzer went up to Horner to ask whether she could audit his class.

“Hi Jack, I’m Mary,” Schweitzer recalls telling him. “I’m a young Earth creationist. I’m going to show you that you are wrong about evolution.”

“Hi Mary, I’m Jack. I’m an atheist,” he told her. Then he agreed to let her sit in on the course.

Over the next 6 months, Horner opened Schweitzer’s eyes to the overwhelming evidence supporting evolution and Earth’s antiquity. “He didn’t try to convince me,” Schweitzer says. “He just laid out the evidence.”

She rejected many fundamentalist views, a painful conversion. “It cost me a lot: my friends, my church, my husband.” But it didn’t destroy her faith. She felt that she saw God’s handiwork in setting evolution in motion. “It made God bigger,” she says.

I’ve read her papers, and they’re real head-scratchers. She seems to do good work; she documents everything carefully; she interprets the results cautiously. They don’t jibe well with expectations — chemistry ought to show more decay — but heck, data is data, if there are sound observations we’ve got to conform the theory to the evidence, not the other way around. She is reporting stuff that seems colossally unlikely, though.

Schweitzer’s most explosive claim came 2 years later in two papers in Science. In samples from their 68-million-year-old T. rex, Schweitzer and colleagues spotted microstructures commonly seen in modern collagen, such as periodic bands every 65 nanometers, which reflect how the fibers assemble. In another line of evidence, the team found that anticollagen antibodies bound to those purported fibers. Finally, they analyzed those same regions with Harvard University mass spectrometry specialist John Asara, who got the weights of six collagen fragments, and so worked out their amino acid sequences. The sequences resembled those of today’s birds, supporting the wealth of fossil evidence that birds descend from extinct dinosaurs.

It’s difficult to believe, but then there’s another dilemma: we expect extraordinarily strong evidence before it should be accepted, but how strong does it have to be? Is this too nitpicky?

She needs more fossils to quiet a continuing drumbeat of criticism. In addition to raising the specter of contamination, Buckley and others have argued that antibodies often bind nonspecifically and yield false-positive results. Critics also noted that one of the six amino acid sequences reported in the 2007 paper was misassigned and is likely incorrect. Asara later agreed and retracted that particular sequence.

“That’s worrying,” says Maria McNamara, a paleontologist at University College Cork in Ireland. “If you are going to make claims for preservation, you really need to have tight arguments. At this point I don’t think we are quite there.”

The biggest problem, though, is this one: all these results come from one and only one lab.

But no one except Schweitzer and her collaborators has been able to replicate their work. Although the study of ancient proteins, or paleoproteomics, is taking off, with provocative new results announced every few weeks, most findings come from samples thousands or hundreds of thousands of years old—orders of magnitude younger than Schweitzer’s dinosaurs.

“I want them to be right,” says Matthew Collins, a leading paleoproteomics researcher at the University of York in the United Kingdom. “It’s great work. I just can’t replicate it.”

That’s something I wish the creationists who bring up her work could understand: we want her to be right. I want to be able to go to a databank and download protein sequences from T. rex. I want to see a molecular phylogenetics comparison of Stegosaurus and Hadrosaurus osteocyte proteins. I think it would be awesome to compare sequences from different ceratopsians and assemble a family tree.

What I want and what we’ve got are two different things, though, and if only Schweitzer has the magic hands to extract this information, I’m not going to trust it. I don’t reject it out of hand, but damn,
it really needs more replication. At this point I don’t want to see another paper from her — I want to see it coming from another, unaffiliated lab. That would be better confirmation.

Cassini must die

It’s happening tomorrow: the Cassini probe is being ordered to destroy itself by crashing into Saturn. It seems harsh. You’ve sent a tourist to an exotic location to go crazy taking vacation snaps, and then instead of a return trip, you reward them with a request to send more pictures of their suicide. I guess it is a spectacular way to go.

And then you learn that those photos were taken with a one megapixel camera. No, really. It’s got some fancy filters to extract more information from its photos, but otherwise, I’ve got better cameras in my electronics junk drawer. It was launched in 1997, so I guess that is to be expected.

Clearly, what this means is that NASA must launch more robots into space with more up-to-date fancy cameras. I know, the budget is tight, but if it will help, I’ll give them the phone out of my pocket — it has a higher resolution camera on it.

Until that next robot goes skyward, you can watch the final moments of Cassini early tomorrow morning. The timing is perfect: it looks like I can just check in right around the time I get up and watch the death of a space probe before I have to go off to work.

Climate change is happening now

You can’t deny it — or rather, you can, but you have to ignore all the evidence. Here’s a list of seven climate hotspots where the shifts are already obvious: southern Spain, Bangladesh, Malawi, the Svalbards in Norway, Brazil, the Philippines, and so the Americans don’t wander off and wonder where those places are, New York. They’re all depressing, but I found the news about the Amazon to be most discouraging.

Perhaps most ominous is the fact that a positive feedback loop appears to be in play. As the Amazon dries, Nobre says, tropical forest will gradually shift to savanna, releasing carbon dioxide into the atmosphere and further adding to global warming.

“When we see a dry season of over four months or deforestation of more than 40 percent then there is no way back. Trees will slowly decay, and in 50 years we would see a degraded savanna. It would take 100–200 years to see a fully fledged savanna.”

The Amazon then would be unrecognizable, along with much of Earth.

We don’t know what all the global consequences of losing the Amazon rain forest would be, but apparently, we’re going to do the experiment and find out.

Meanwhile, there are still people who believe it’s not a problem, and that market forces will compensate for our new hot, dry, stormy, flooded reality. The scientific research is 97% in agreement, which is already remarkable, given how much scientists like to argue. And the other 3% is junk science.

But what about those 3% of papers that reach contrary conclusions? Some skeptics have suggested that the authors of studies indicating that climate change is not real, not harmful, or not man-made are bravely standing up for the truth, like maverick thinkers of the past. (Galileo is often invoked, though his fellow scientists mostly agreed with his conclusions—it was church leaders who tried to suppress them.)

Not so, according to a review published in the journal of Theoretical and Applied Climatology. The researchers tried to replicate the results of those 3% of papers—a common way to test scientific studies—and found biased, faulty results.

Katharine Hayhoe, an atmospheric scientist at Texas Tech University, worked with a team of researchers to look at the 38 papers published in peer-reviewed journals in the last decade that denied anthropogenic global warming.

“Every single one of those analyses had an error—in their assumptions, methodology, or analysis—that, when corrected, brought their results into line with the scientific consensus,” Hayhoe wrote in a Facebook post.

But of course it is that flawed 3% our elected officials have chosen to accept, and we don’t have a mechanism for removing deluded idiots from office.

One must have a goal

Here’s a good one: a step-by-step recipe to becoming a fossil. Yes! I think I can do this!

Step 1 is to die. I will probably be able to do this without too much problem, but I think I’d rather wait a little while.

Step 2 is neglect. Your corpse shouldn’t be dismantled, shredded, consumed, etc. I think I can do that one, too!

So far, this is looking easy.

Step 3 is burial, also achievable. First catch, though: soil chemistry matters. This is not usually on the list of options at the mortuary. Burial under volcanic ash is mentioned as specifically a bonus, also not usually a service provided by the undertaker.

Step 4 is…fossilization? Wait a minute, all that other, easy stuff is just a prelude? Dang. And then this step looks like it’s strongly chance dependent.

Oh, well. At least the procedure doesn’t look like I’ll have to do any work, which is good, since I’ll be dead through most of it.

Everyone ought to love a colonoscopy

I am a bad, foolish person, and now I’m feeling guilty. A few years ago, I made an appointment for a colonoscopy, and then what happened? Work happened, and I had to cancel my appointment. The prep work for the scan is unpleasant, and I knew it was going to mess up at least a day, and I couldn’t afford the time just then.

Worse, after canceling, I didn’t make another appointment. I’m just letting it slide. You know, that’s stupid. Especially after opening the latest issue of JAMA this morning and reading an editorial, Using Outreach to Improve Colorectal Cancer Screening. Early diagnosis of colon cancer makes a huge difference in prognosis, so you’d have to be an idiot to put it off.

Colorectal cancer (CRC) is the second leading cause of cancer death in the United States, with more than 50 000 deaths expected in 2017. Screening can reduce CRC mortality, and several methods of screening are available and recommended for average-risk adults aged 50 years to 75 years. Modeling studies suggest that several different methods of screening produce relatively similar levels of mortality reduction if there is good adherence to the underlying screening program.

Despite strong evidence of effectiveness, more than a third of age-eligible US adults are not up-to-date with CRC screening, with important disparities by ethnicity, income, education, and availability of a regular source of care. Currently, most CRC screening in the United States is achieved by colonoscopy. Studies of audiotaped encounters suggest that few clinicians and patients are having high-quality, shared discussions about screening options.

Increasing screening levels to greater than 80% has the potential to prevent an estimated 200 000 deaths in the United States in less than 20 years.

At least I’m not alone in my stupidity — a third of people in my cohort have been blowing it off. That’s no excuse, of course. Knowing that there are tens of millions of people in my situation does not make it less derpy.

So…I’m going to call in and make an appointment today. There’s a long wait time around here, so I probably won’t get in until Decemberish, which is all the more reason to call now.

Much of the editorial is about how health care providers can better inform and encourage people to get screened, and assessments of the effectiveness of various methods. I’m not a doctor, so I’ll just mention that I think outreach like Crispian Jago’s cancer diary helps me realize how important this is — and although it would be convenient to complain that my local hospital should have followed up with me after my canceled appointment, the truth is it’s all on me. And on you. If you’re over 50, contact your physician and make arrangements, if you haven’t already.

It’ll be fun! Weird liquid diets and spending a day purging your bowels so they can slide a camera up your butt? How can it not be exciting?

How to model a universal butt

Fascinating — models in software games have some subtle but intentional design features. There is a game character in Overwatch (which looks like a fun game, but since it’s PC only, I’ve never tried it) named Tracer who was the focus of some controversy a while back because some of the promotional materials emphasized her lovely, shapely butt maybe a bit overmuch. Now there has been a detailed analysis of the design of her character to identify what makes her butt so nice in every view.

Wu discovered that the primary cause of Tracer’s plump backside is an inhumanly deep buttcrack. In fact Tracer has a butt crack so deep that regular humans could not possess similar physiology and survive. Such a crack would inevitably interfere with organs and the body’s structural integrity.

As a result of this bizarrely deep posterior, Tracer can be put in literally any pose, under any lighting, and her butt will still cast a shadow implying depth, plumpness and tautness. The way Tracer’s bottom is emphasised in any situation is a genuine feat of engineering.

On top of that, there’s more. Another aspect of Tracer’s butt that plays a big part in its eternal visibility is the fact that her outfit is either impossibly tight or glued to her ass cheeks.

Take a look at the image on the far right. Natural fabric would find a resting point between the peaks of the two cheeks, naturally bridging the gap. If the material pulls in to show cheek definition, this would be the result of both cheeks physically trapping the fabric. This is different, in that the fabric follows the contours of the cheeks and buttcrack without the two cheeks making contact. For the titillation of boys and girls worldwide, Tracer suffers a permanent wedgie that is literally designed to make her individual butt cheeks shine.

Wait, but what about realism? What about ethics in gaming?

We’ll get to that once I’m done marveling that there is such a thing as virtual butt analysis, and that there are game designers and artists working hard to maximize butt exposure.

Nature is also working on it. Check out Jon Snow’s butt.