A region well-known for coffee, depression, and fatalism

pnwrupture

It’s very strange to see all the hullabaloo about this New Yorker article on imminent catastrophic demise of the Pacific Northwest. I grew up there, I consider it one of the best places in the world to live, and most of my family still lives there…I ought to be horrified, terrified, and frantically calling my mother and telling her to move.

Unfortunately, we get this same story every few years. I lived in the Green River Valley, and every once in a while someone would notice that all that fertile farmland was built on top of a pyroclastic mudflow, and the valley was actually a great big chute for deadly lahars from Mt Rainer to the gates of Seattle.

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Normalizing the intolerable

hamsterwheel

I tell you, the Careers section of Science magazine is a perpetual source of pain and aggravation. In the latest, Eleftherios Diamandis explains exactly what you need to do to be a success in science. The secret, apparently, is to be noticed, and the way to be noticed is…by doing exactly the same thing all the other lab rats on the exercise wheel are doing.

Be an excellent scholar. Publish well. Work hard. Communicate with the public and your peers. But a well-planned, long-range effort to ensure your visibility among those who have hiring responsibilities can be the deciding factor.

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Friday Cephalopod: Adorable! I will name him George and I will hug and pet him and squeeze him!

bluerings

Uh, maybe not. What if it gives you a tiny little nibble?

Now, 10 minutes later, you notice something strange. Your lips are going numb. So is your face. You want to yell for help but can’t: It’s getting harder to speak. And your stomach feels—oh, gross! Right in front of everyone.

Somebody calls an ambulance. It’s getting tough to stand. It’s getting tough to breathe. The numbness is spreading to your hands, feet, and chest. And you continue to be aware for every agonizing moment of it.

You get to the hospital in time. You get hooked up to a ventilator, the machine forcing air into your lungs because your diaphragm is paralyzed. No antidote, the doctors say. You have to wait it out. About 15 long hours later, your muscles start working again. They take you off the ventilator. You can breathe.

Don’t run, learn

That story about an arrogant surgeon? It’s gone. Totally deleted.

Of note, “Hope” has since deleted her blog and Twitter account.

After consideration of your feedback on Twitter, consultation with the MedPage Today editorial team, and analysis by “Orac” at Respectful Insolance, and Peter Lipson and Janet D. Stemwedel at Forbes, I have removed the story from the website.

Whoa. That’s not a good response to what ought to be a “teaching moment”.

They’re only bugs

os-air-potato-bug

There is an important research facility in Florida that studies exotic insects and invasive species. You’d think a state like Florida, which is swarming with invasive plants and animals, would consider this a useful and practical operation.

The UF/IFAS (Institute for Food and Agriculture) quarantine facility is a highly secure state of the art lab in Ft. Pierce.

Security is top priority because if any insects were to escape, their impact in our environment would be unclear.

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More doctors behaving badly

shit_for_brains

You didn’t get enough yesterday? Here’s another gag-inducing story from Jonathan Eisen. A while back, an MD at UC Davis tried an experimental cancer treatment on three patients: to amplify the immune response to a glioma, they injected fecal bacteria into the patients’ heads.

Two UC Davis neurosurgeons were treating terminally ill brain cancer patients with an unapproved, experimental treatment that is referred to as “Probiotic Intracranial Therapy for Malignant Glioma”. The treatment involved purposefully infecting patients brains with a bacterium Enterobacter aerogenes apparently because of prior anecdotes and case reports that suggested that patients with these brain cancers who also had brain infections might live longer than those with the cancer but without the infection. According to the article, there was an investigation at UC Davis into the practices of the surgeons. It was determined by UC Davis that they did not have IRB approval to carry out the treatments and that there were some other issues with the practice going on. At the conclusion of the investigation UC Davis wrote a letter to the FDA detailing the case and has banned the two neurosurgeons from performing medical research on humans.

Notice that key statement? No IRB approval. They just skipped that whole institutional review thing and squirted something radical, untested, and backed only by anecdote into the heads of very sick people. Two died within weeks, another died a year later.

What happened to the doctors? They left UC Davis after a review found their behavior unethical.

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