OK, gang, help me out here. I’m swamped today — my morning is destroyed because I have to go in to the clinic for my annual thorough extensive physical check-up, and I get out just in time for my afternoon class, and then I’m free, sort of. Except that I have to compose a 10 question online quiz on chromosome variations.
So give me some good questions on deletions, duplications, inversions, and translocations. Preferably questions that can be easily machine-scored, but I do throw in an essay question or two.
Get to work. I’ll expect them in the comments section here when I get back at 1:30.
Don’t disappoint me.
Maybe too easy:
What explains the difference in the number of chromosomes between H. Sapiens (46) and other simians (e.g. the 48 of Pan troglodytes)? What evidence supports supports this?
Assuming that Cheez-Whiz is derived from “Cheez”, and Cheez is a mutant strain of actual Cheese, how would the original Cheese’s chromosomes differ from the final product?
Support your conclusion with peer-reviewed citations (or lots of exclamation points).
How does trisomy 21 happen in 95% of cases ?
a) Meiotic Nondisjunction (95% of cases): The egg or sperm cell retains both copies of chromosome 21 instead of one, resulting in a zygote with three copies.
this one seems a bit basic. I probably could have done better but I’m tired.
What is the sound of one endonuclease clipping?
In de la Chapelle syndrome, SRY translocates from the y chromosome onto the X chromosome in meiosis prior to the formation of a genetically XX zygote. These individuals are usually:
a) Phenotypically female due to XX karyotype
b) Phenotypically female due to downstream development of the Mullerian ducts
c) Phenotypically male due to SRY activation of SOX9
d) Phenotypically male due to downstream development of the Mullerian ducts
A rather short gene has the following sequence:
TACGAGTAAATT
If the first C is deleted, which of the following is most likely to occur:
a) the gene is never transcribed due to destruction of its promoter sequence
b) the transcript is never translated due to destruction of the start codon
c) the initial methionine is changed to an isoleucine
d) all peptides in the protein are altered due to frame shifting