In Twilight Struggle, if you cause nuclear war, your opponent wins and you lose. Twilight Struggle is a two-player strategy game that simulates The Cold War. As you know, in the real world, if there is a nuclear war then everyone loses. But in Twilight Struggle, nuclear war leads to one winner and one loser. This speaks to limitations in what a strategy board game can effectively simulate.
Twilight Struggle is simulating a semi-cooperative situation, which means it combines cooperative and competitive elements. A semi-cooperative game is one that allows one player to get ahead of the other, but also allows outcomes which are good for both players or bad for both players. Note that ties don’t count, because they aren’t good or bad for both players! A semi-cooperative game requires at least three distinct outcomes, outside of ties. In Twilight Struggle, the three outcomes are USA wins, the Soviet Union wins, or there is nuclear war. This is challenging to adapt to a board game format, because players are accustomed to only two non-tie outcomes: winning or losing.